Here at CREA, we deal solely with assisted human reproduction. We have been a pioneering centre for reproductive medicine for more than 20 years, lead by the highest quality trail-blazing professionals in this field. Our success is based on the fact that we are a really close-knit team.
Our treatments are state-of-the-art
If you want to know more about CREA and Assisted Reproduction treatments, please click here
“We love what we do”
We can certainly offer the very best results in infertility treatment through the use of the most up-to-date methods. Our results vouch for themselves, allowing us to be the leaders in Spain in fertilization success stories for the whole country.
“Our results are consistent and reliable“
Our patients come first and they are our number one concern. That’s why we have a dedicated team of personnel made up of totally committed professionals, whose main tasks are outstanding work ethics and performance. We offer the best care quality.
“We want all our patients to feel supported, comfortable and in good hands”
We have a tailor-made international department set up specially to take care of our visitors from overseas. Their mission is to forge a direct link between the patient’s medical team in their home country, and the one in CREA.
“To allow for a smooth flow of information and let the team deal with any unforeseen issues”
The clinic is equipped with a recently expanded brand new extension, where our clients will find themselves in a warm and cosy environment right from the start.
The embryology lab at CREA is possibly one of the most advanced in Europe, and is set up with the safest and most modern technology.
“You’ll feel right at home”
The clinic is located in a prime location in downtown Valencia, together with being able to offer a complete range of solutions for each specific infertility issue.
“We always choose quality and safety”
Our integrated continuous quality control programme is fully approved. We were one of the first Spanish centres to be awarded the ISO 9001 Quality Certificate, and we undergo one of the most rigorous and prestigious world-class audits proving CREA’s excellence at an international level.
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At CREA we think for you and about you, because we make wishes come true - we make life.
QUALITY AND SAFETY CAN NEVER BE LOW COST
Editorial by Dra. Carmen Calatayud , Co-Director of CREA
The economic crisis we have been suffering for some years now has meant cost cutting across the board. In the case of healthcare, this can have dire consequences. Throughout our sector several “Low Cost” assisted reproduction clinics have appeared, offering reductions in their pricing as the name itself suggests. Logically, this also means that their care quality leaves much to be desired.
Reproductive medicine is in itself a very costly type of treatment because it requires the use of top quality resources, which are in turn expensive to provide. The sector is multi-disciplinary, bringing together the expertise of different highly-trained individuals who are always refreshing their skills so as to be at the top of their game in the field. A high performance clinic requires a large, well-qualified team to be able to comply with all quality needs that this specialty demands.
To be able to comply with all of this, it is vital to invest constantly in training, to attend international symposiums so as to be at the forefront of the latest techniques as well as performing R & D as well as carrying out and publishing research projects.
In the same manner, a large proportion of resources must be set aside to provide the Centre with the best available technology, thus allowing for a safer and more reliable treatment regime geared to giving the best results. Many of the investments made are not, and will not be, profitable with regards to cost factors, but they do allow for the carrying out of treatments with much greater safety and accuracy. This is the common goal for both the specialists as well as the patients. A fine example of this is the use of lasers to perform embryonic biopsies, or carrying out assisted hatching instead of using mechanical or chemical means, which are much cheaper but may damage the embryo.
So as to comply with this quality commitment, a full-time qualified team of people is required who must be provided with all the necessary tools to minimize any type of risk. Laboratory safety is our main goal, and because of this one of the measures we have in place is to ensure that our embryologists always work in pairs throughout each process. In this way, each one carries out quality control over the other team member. This can only happen if there are a sufficient number of embryologist staff members working together. There are minimum staff member requirements depending on the number of the cycles being performed, as the attention needed by the embryos in the laboratory must be personalized and is time critical, this cannot be achieved without sufficient personnel.
In addition, neither ovaries nor embryos follow the calendar, and this means full-on twenty-four-seven exclusive attention by our workforce. Again, low cost organisations also carry out cut backs in this area so as to save duty-staff salaries.
Investment is required in infrastructure, not only to provide personalised maximum attention to patients, but also to have the very best medical materials available together with in-house services. This means there is no depending on third parties, and even though this sort of investment may appear not to be particularly profitable, it certainly provides a more reliable outcome.
An embryology laboratory must never be shy of making any type of investment to ensure a safety guarantee. Here we are talking about embryos which are extremely sensitive to any ambient changes, whether they be humidity, temperature or air quality. This requires in-depth full-time vigilance and control. Our laboratories have these procedures in place twenty-four hours per day so as to detect any possible variation in any of the abovementioned parameters. If and whenever any anomaly occurs, alarms linked to at least three staff members from each laboratory are then set off.
This safety control system is set up in our embryonic storage tanks, as well as in the egg and sperm banks. Our banks are equipped with a continuous liquid nitrogen top up system, allowing their vapour levels to be kept at just the right setting at all times. If this is not carried out, the frozen embryos, eggs or sperm inside may go to waste. This is not possible with conventional cryogenic flasks where the on-duty biologist is required to measure the nitrogen levels every day and the top them up manually. With this method, it is not possible to have a reliable record twenty-four hours per day, 365 days per year like we do.
Another major point to be considered with regards to the laboratory is air quality. European rulings on laboratory air quality requirements are very well set out, and this is why we have carried out major investment in this area so as to achieve full compliance. Not only does all of this require a significant outlay for the initial infrastructure, but also a follow up maintenance programme of the whole set up carried out by a specialist outside maintenance service well versed in sterile environments. These specialists perform atmosphere control tests as well as pathogen screening, so as to avoid any type of contamination which may affect the embryos. Not all reproductive medicine clinic laboratories have taken on board this European ruling, even though they are required to do so.
Advances in reproductive medicine technology have allowed us to obtain the very best in embryonic culture conditions, which in turn has lead to top results in full-term pregnancies with healthy births. This has come about due to us abandoning the use of conventional incubators years ago in favour of Benchtop incubators. These devices work in controlled hypoxic conditions which is the very best environment for perfect embryonic development. This improvement in embryo quality has allowed us to grow our embryos up to the blastocyst stage. This factor is extremely important, because for an embryo to implant, it must have developed to this stage and, if it is transferred before this and a pregnancy is not achieved, it is impossible to know if it has been caused by an interruption in its development. In the same way, we only vitrify the excess embryos after they have reached the blastocyst stage, because they are the ones which have some real possibility of offering a pregnancy. It is preferable not to transfer rather than transferring a non-viable embryo.
To mention just a few of the things that patients are unable to see are: the levels of quality in the embryology laboratory; the culture methods; the incubators; the control set up of the working conditions with their embryos; the medical gases used; the careful control of pH levels as well as the temperature. Many people are unaware of the care and dedication with which the work is carried out, as well as the professionalism and skill with which the embryologists work, knowing that every step in each procedure has set times, and that exceeding these is unacceptable. Working under this type of pressure is relieved by having sufficient personnel available along with support from the very best infrastructure.
There is just one specific assisted reproduction laboratory certification offering quality standards known as the UNE-179007. For it to be awarded, this system requires an enormous effort with regard to human and financial resources. However, it does offer a quality guarantee and it sets apart the clinics that do have it from the rest. At the present time in Spain very few of us, in fact fewer than 5% among the 300 assisted reproduction clinics on offer, have this quality guarantee.
All this outlay in infrastructure allows us to not only dedicate the required time to the patients so as to carry out a thorough diagnosis to evolve the right treatment, but to also to offer them supplementary techniques which will offer them the assurance of having a healthy child to have at home.
It is as important to study the female as well as the male. This is the reason why an assisted reproduction clinic must have an Andrologist available, so as to evaluate the male partner and treat any andrology issues which may be present before the couple undergoes any kind of assisted reproduction treatment. The better the gamete quality, the more possibility of having a healthy child there is.
It is also fundamental for a quality centre to have a psychology department which can offer patient help and support, because the emotional pressures involved with infertility issues, as well as treatment are no small thing, so having expert help is a must.
Not all treatments can be performed in the same way for everyone, neither can a treatment be repeated after an unsuccessful attempt without having looked carefully into possible new causes for that failure. Because of this, we at CREA carry out weekly clinical sessions where cases are looked into both from a medical point of view as well as the embryo laboratory development side. Any supplementary diagnoses or therapeutic tests which may increase success rates are assessed.
The stringent levels of demand required for each process must be applied by each centre, and all team members must be aware of the importance that of this has. One fine example of this is our strict choice of donors, both for egg as well as sperm. Throughout all the time we have had gamete banking, we have only accepted 5% of the candidates because our selection criteria are extremely high, thus allowing us to maintain our quality levels.
The main difference between a low cost centre and a quality one is the company philosophy. A top quality centre will invest in highly qualified operatives, the best infrastructure and the very best resources so that their patients can achieve the dream of becoming parents. This can never be compared with anywhere else where short-term profitability, as well as doubtful work ethics, are things which are decided on by the capital investors who own the business.
Investment in safety is costly and is proportional to the cost of the cycles.
To sum up, the goal of both future parents, as well as the professionals involved, is the birth of a healthy child; there is no room for cut backs from the crisis in this fine undertaking.